I’ve been a Seesmic Desktop user for as long as I can remember, though I started my Twitter desktop experience switching between Tweetdeck and Twhirl a long time ago. I ended up sticking with Seesmic Desktop when I started maintaining multiple Twitter accounts – I currently manage 4 different accounts, including my personal one. However, there’s a few things I really hate about Seesmic Desktop.
For starters, Seesmic Desktop doesn’t look like a Windows app – it looks like an OS X app that’s installed on my Windows machine. It behaves funny, and things just generally aren’t where I expect them to be. It’s also quite boring, with just a single brushed-metal color scheme and no options to change that.
Tweetdeck, on the other hand, looks and feels like a Windows app, which makes me more comfortable. It also has color schemes so I can tinker a bit here and there, and generally offers far more customization than Seesmic Desktop does.
There is, however, one thing that you can do in Seesmic Desktop that you cannot do in Tweetdeck – have a single ‘mentions’ column for all your accounts. This may not matter to you, but for me, it’s key, and for a long while has been the sole reason I keep using Seesmic Desktop instead of Tweetdeck.
Another drawback to Seesmic Desktop, though, is that it does not run well on netbooks. On my Asus 1000HE (which has 2GB of RAM), I cannot have Seesmic Desktop and Last.FM running at the same time – the music will skip and buffer endlessly. Tweetdeck, fortunately, runs smoothly.
So, how do you get the aforementioned single mentions column in Tweetdeck? By searching, of course.
Tweetdeck allows you to create custom search columns for specific keywords, and it supports the ‘OR” modifier. So, simply create a search column with your various usernames, separated by ‘OR”. Mine is ‘@rcadden OR @symbianguru OR @maemoguru OR @thesymbianguru‘. Done and done.
(@thesymbianguru is a private account that I use to communicate with the other contributors to Symbian-Guru.com. Don’t bother requesting to follow me there, it’ll be ignored. Catch me at @rcadden (personal) or @symbianguru (Symbian-related)
What is your chosen desktop Twitter client? Why do you prefer that one?
Ricky Cadden 
Is there any way to have this work with Twitter AND Facebook like the “Me” column on the Android Tweetdeck?
Hey, actually in Tweetdeck for Chrome, you can have single mention box for all your connected accounts. I just found about it myself yesterday.